Course 5: Opioid Trials: Determining Design, Efficacy, and Safety

Last Reviewed: January 7, 2020

What You’ll Learn

  1. Identify appropriateness of opioid therapy based on patient population, pain type, and pattern
  2. Determine the efficacy and safety of an opioid trial for an individual patient
  3. Design an opioid trial based on pain type, patterns, and patient factors

What You’ll Earn

CAPC members can earn the following free continuing education credits:

  • Medicine: 0.75 CME, 0.75 ABIM MOC (Medical Knowledge Only)
  • Nursing: 1.00 CNE, 0.75 Pharmacotherapy

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Tools & Resources


Course 5: Patient Story

Last Updated: January 29, 2019

Case examples used in the CAPC curriculum to illustrate pain management techniques.


Course 5 References: Opioid Trials - Determining Design, Efficacy and Safety

Last Updated: January 29, 2019

Course citations. Center to Advance Palliative Care, 2015.


Sample Treatment Agreement/Informed Consent Form

Last Updated: January 29, 2019

Documentation of patient and clinician goals and expectations for safe and effective opioid treatment.

Constipation Protocol

Last Updated: March 20, 2020

Sample protocol for managing constipation. Organizations can create similar protocols in collaboration with referring clinicians and pharmacists. Lee Health, 2013.


Pain Management Glossary

Last Updated: March 20, 2020

Key terms related to pain and pain management. Center to Advance Palliative Care, 2015.


Prescribing Opioids: A Pocket Reference

Last Updated: March 17, 2020

Opioid pocket reference for providers including safe starting doses, equianalgesic chart, and standard dosing strengths. Center to Advance Palliative Care, 2019.


Analgesics Fact Sheet

Last Updated: March 20, 2020

When to use - and when to avoid - 6 classes of analgesics including acetaminophen, NSAIDs, opioids, antiepileptics, antidepressants, and corticosteroids. Center to Advance Palliative Care, updated 2018.


Pain Intensity Score

Last Updated: January 29, 2019

The 0-10 Numeric Pain Intensity Scale is the most commonly used pain intensity scale and is based on self-report.


Opioid Risk Tool (ORT)

Last Updated: January 29, 2019

Validated 5-question assessment tool designed to predict which patients are at risk for opioid substance use disorder.


Constance Dahlin, MSN, ANP-BC, ACHPN, FPCN, FAAN. Consultant, Center to Advance Palliative Care.

Jaime Goldberg, MSW, LCSW, ACHP-SW. PhD student, University of Wisconsin-Madison School of Social Work.

Philip Higgins, PhD, LICSW. President, Lighthouse Counseling of Salem, Inc.

Lynn Hill Spragens, MBA. Partner, Spragens & Gualtieri-Reed.

Jay R. Horton, PhD, ACHPN, FNP-BC, MPH, CENP. Director of Nursing Safety, Quality, and Performance Improvement Mount Sinai Hospital. Assistant Professor Department of Geriatrics and Palliative Medicine Icahn School of Medicine at Mount Sinai.

Khadidjatou Kane, MD. Oncology Hospitalist, Assistant Professor of Hospital Medicine, Northwestern University Feinberg School of Medicine.

Lolita Melhado, MSN, ARNP, FNP-BC. Family Nurse Practitioner/Palliative Care, Gulf Coast Medical Center - Lee Memorial Health System.

Bridget Montana, MSN, APRN, FPCN, MBA. Hope HealthCare Services, Chief Operating Officer.

Colleen Mulkerin, MSW, LCSW. Director Palliative Care Consult Service, Hartford Hospital.

Drew Rosielle, MD, FAAHPM. Palliative Care, Fairview Health Services, University of Minnesota Medical School.

David Weissman, MD. President, Palliative Care Education, LLC.

Sherika S. Newman, DO. Hospice & Palliative Medicine, Family Medicine Piedmont Healthcare.*

Karl Bezak, MD. Clinical Assistant Professor of Medicine, Palliative Care and Medical Ethics, University of Pittsburg (UPMC).*

Sivan Ben-Moshe, MD. Fellow, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai.

Sachin Kale, MD. Fellow, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai.

Katie Wang, MD. Fellow, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai.

*indicates ABIM Peer Reviewer

Contact information: For technical questions about online activity or continuing education credits, contact or 212-201-2674.

Provided by the Icahn School of Medicine at Mount Sinai.

The Courses

Course 1: Comprehensive Pain Assessment

Conducting a comprehensive pain assessment to guide safe and effective treatment.

Course 2: Matching the Drug Class to the Pain

Selecting a safe and appropriate analgesic for patients with serious illness based on the pain asse…

Course 3: Patient Factors that Influence Prescribing Decisions

Patient and family factors that influence prescribing decisions for patients with serious illness.

View all courses in the unit

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