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Next Reply: Re:Infused combination meds for nausea
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Post Infused combination meds for nausea
Author: jamulder
Date: Nov 14, 2008 2:56 pm
My hospital has requested data from me regarding the use of combination antiemetic therapy by infusion, specifically what other hospitals may be using. I've historically used Ativan/Benadryl/Decadron. I'd appreciate any experiential or anecdotal info from anyone else who has used this or other recipies. Thanks!
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Re:Infused combination meds for nausea (by mrabow on 11/20/2008)
Hi, Although we haven't yet seen any responses to your query, there are a lot of anti-emetic combinations being used. Others... please weigh in... in the mean time, a few thoughts: Although treating nausea is the central goal, consideration can be paid to other potential goals and side effects of combinations. For example, how much sedation is desired or tolerable? Are there other reasons to have someone on a steroid (Dexamethasone)? Is the potentiation of opioid analgesia a goal (as can be achieved with phenergan)? Some other common combinations include: metoclopramide, dexamethasone, and lorazepam; ondansetron and dexamethasone; ondansetron plus droperidol. Numerous chemo regimens include Aprepitant plus ondansetron and dexamethasone. For a nice paper on the pathophysiology behind choosing anti-emetics check out Gordon J. Wood, MD; Joseph W. Shega, MD; Beth Lynch, NP; Jamie H. Von Roenn, MD JAMA. 2007;298:1196-1207. Best, Mike Michael W. Rabow, MD Associate Director, UCSF Palliative Care Leadership Center

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