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CAPC Palliative Care Discussion Forum
General Operational Topics
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Best,
Michael Rabow, MD, Associate Direcdtor, UCSF Palliative Care Leadership Center.
We use Ativan, which I have found very dissappointing. Half the time it makes the patient worse, and if it works, you have to sedate the patient into unconsciousness before they stop shouting or crawling out of bed.
Terminal delirium may be different than sepsis/hospital related delirium, but in sepsis induced delirium, brain dopamine levels are high and acetylcholine levels are low, and I have been having a better response from Haldol 1-3 mg now and tid (routine), and donepizel/Aricept 5 mg now and q pm. than I ever got with prn dosing of haldol or with haldol alone.
Terminal delirium may be different in that reticular activating system failure is at least part of what is going on. In one case I had excellent results adding Ritilan 5 mg po @ 8:00, 10:00, 12:00, 2:00. The patient woke up and remained responsive to the family until just a few hours before death.
It can be hard to convince a nurse to give Ritalin to an agitated patient, but it is kind of like ADD. Improved RAS function is calming.